LymphedemaV1, Main, Exploration, bibRecord, 005862

Human Lymphatic Architecture and Dynamic Transport Imaged Using Near-infrared Fluorescence12

Identifieur interne : 005862 ( Main/Exploration ); précédent : 005861; suivant : 005863

Human Lymphatic Architecture and Dynamic Transport Imaged Using Near-infrared Fluorescence12

Auteurs : John C. Rasmussen [États-Unis] ; I-Chih Tan [États-Unis] ; Milton V. Marshall [États-Unis] ; Kristen E. Adams [États-Unis] ; Sunkuk Kwon [États-Unis] ; Caroline E. Fife [États-Unis] ; Erik A. Maus [États-Unis] ; Latisha A. Smith [États-Unis] ; Kyle R. Covington [États-Unis] ; Eva M. Sevick-Muraca [États-Unis]

Source :

Translational Oncology [ 1936-5233 ] ; 2010.

RBID : PMC:3000461

Abstract

BACKGROUND: Although the importance of lymphatic function is well recognized, the lack of real-time imaging modalities limits our understanding of its role in many diseases. In a phase 0 exploratory study, we used dynamic, near-infrared (NIR) fluorescence imaging to assess the extremes of lymphatic architecture and transport in healthy human subjects and in subjects clinically diagnosed with unilateral lymphedema (LE), a disease that can be prevalent in cancer survivors. METHODS AND RESULTS: Active lymphatic propulsion was imaged after intradermal injections of 25 µg of indocyanine green (total maximum dose ≤400 µg) bilaterally in the arms or legs of control and subjects. Images show well-defined lymphatic structures with propulsive dye transport in limbs of healthy subjects. In LE subjects, we observed extravascular dye accumulation, networks of fluorescent lymphatic capillaries, and/or tortuous lymphatic vessels in all symptomatic and some asymptomatic limbs. Statistical models indicate that disease status and/or limb significantly affect parameters of apparent lymph propagation velocity and contractile frequency. CONCLUSIONS: These clinical research studies demonstrate the potential of NIR fluorescence imaging as a diagnostic measure of functional lymphatics and as a new tool in translational research studies to decipher the role of the lymphatic system in cancer and other diseases.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000461

PubMed: 21151475
PubMed Central: 3000461

Affiliations:

États-Unis

Le document en format XML

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<author><name sortKey="Rasmussen, John C" sort="Rasmussen, John C" uniqKey="Rasmussen J" first="John C" last="Rasmussen">John C. Rasmussen</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Adams, Kristen E" sort="Adams, Kristen E" uniqKey="Adams K" first="Kristen E" last="Adams">Kristen E. Adams</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Kwon, Sunkuk" sort="Kwon, Sunkuk" uniqKey="Kwon S" first="Sunkuk" last="Kwon">Sunkuk Kwon</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine at the University of Texas Health Science Center at Houston, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine at the University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea>
<wicri:noRegion>TX</wicri:noRegion>
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<author><name sortKey="Fife, Caroline E" sort="Fife, Caroline E" uniqKey="Fife C" first="Caroline E" last="Fife">Caroline E. Fife</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Internal Medicine, Division of Cardiology and Hyperbaric Medicine at The University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea>
<wicri:noRegion>TX</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:aff id="A3">Memorial Hermann Hospital, Center for Lymphedema Management, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Memorial Hermann Hospital, Center for Lymphedema Management, Houston, TX</wicri:regionArea>
<wicri:noRegion>TX</wicri:noRegion>
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<author><name sortKey="Maus, Erik A" sort="Maus, Erik A" uniqKey="Maus E" first="Erik A" last="Maus">Erik A. Maus</name>
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<wicri:regionArea>Department of Internal Medicine, Division of Cardiology and Hyperbaric Medicine at The University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea>
<wicri:noRegion>TX</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:aff id="A3">Memorial Hermann Hospital, Center for Lymphedema Management, Houston, TX, USA</nlm:aff>
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<wicri:regionArea>Memorial Hermann Hospital, Center for Lymphedema Management, Houston, TX</wicri:regionArea>
<wicri:noRegion>TX</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smith, Latisha A" sort="Smith, Latisha A" uniqKey="Smith L" first="Latisha A" last="Smith">Latisha A. Smith</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Department of Internal Medicine, Division of Cardiology and Hyperbaric Medicine at The University of Texas Health Science Center at Houston, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Internal Medicine, Division of Cardiology and Hyperbaric Medicine at The University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea>
<wicri:noRegion>TX</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:aff id="A3">Memorial Hermann Hospital, Center for Lymphedema Management, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Covington, Kyle R" sort="Covington, Kyle R" uniqKey="Covington K" first="Kyle R" last="Covington">Kyle R. Covington</name>
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<wicri:regionArea>Department of Internal Medicine, Division of Cardiology and Hyperbaric Medicine at The University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea>
<wicri:noRegion>TX</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:aff id="A3">Memorial Hermann Hospital, Center for Lymphedema Management, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Sevick Muraca, Eva M" sort="Sevick Muraca, Eva M" uniqKey="Sevick Muraca E" first="Eva M" last="Sevick-Muraca">Eva M. Sevick-Muraca</name>
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<country xml:lang="fr">États-Unis</country>
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<front><div type="abstract" xml:lang="en"><p><italic>BACKGROUND:</italic>
 Although the importance of lymphatic function is well recognized, the lack of real-time imaging modalities limits our understanding of its role in many diseases. In a phase 0 exploratory study, we used dynamic, near-infrared (NIR) fluorescence imaging to assess the extremes of lymphatic architecture and transport in healthy human subjects and in subjects clinically diagnosed with unilateral lymphedema (LE), a disease that can be prevalent in cancer survivors. <italic>METHODS AND RESULTS:</italic>
 Active lymphatic propulsion was imaged after intradermal injections of 25 <italic>µ</italic>
g of indocyanine green (total maximum dose ≤400 <italic>µ</italic>
g) bilaterally in the arms or legs of control and subjects. Images show well-defined lymphatic structures with propulsive dye transport in limbs of healthy subjects. In LE subjects, we observed extravascular dye accumulation, networks of fluorescent lymphatic capillaries, and/or tortuous lymphatic vessels in all symptomatic and some asymptomatic limbs. Statistical models indicate that disease status and/or limb significantly affect parameters of apparent lymph propagation velocity and contractile frequency. <italic>CONCLUSIONS:</italic>
 These clinical research studies demonstrate the potential of NIR fluorescence imaging as a diagnostic measure of functional lymphatics and as a new tool in translational research studies to decipher the role of the lymphatic system in cancer and other diseases.</p>
</div>
</front>
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<name sortKey="Covington, Kyle R" sort="Covington, Kyle R" uniqKey="Covington K" first="Kyle R" last="Covington">Kyle R. Covington</name>
<name sortKey="Fife, Caroline E" sort="Fife, Caroline E" uniqKey="Fife C" first="Caroline E" last="Fife">Caroline E. Fife</name>
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<name sortKey="Kwon, Sunkuk" sort="Kwon, Sunkuk" uniqKey="Kwon S" first="Sunkuk" last="Kwon">Sunkuk Kwon</name>
<name sortKey="Marshall, Milton V" sort="Marshall, Milton V" uniqKey="Marshall M" first="Milton V" last="Marshall">Milton V. Marshall</name>
<name sortKey="Maus, Erik A" sort="Maus, Erik A" uniqKey="Maus E" first="Erik A" last="Maus">Erik A. Maus</name>
<name sortKey="Maus, Erik A" sort="Maus, Erik A" uniqKey="Maus E" first="Erik A" last="Maus">Erik A. Maus</name>
<name sortKey="Sevick Muraca, Eva M" sort="Sevick Muraca, Eva M" uniqKey="Sevick Muraca E" first="Eva M" last="Sevick-Muraca">Eva M. Sevick-Muraca</name>
<name sortKey="Smith, Latisha A" sort="Smith, Latisha A" uniqKey="Smith L" first="Latisha A" last="Smith">Latisha A. Smith</name>
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<name sortKey="Tan, I Chih" sort="Tan, I Chih" uniqKey="Tan I" first="I-Chih" last="Tan">I-Chih Tan</name>
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Serveur d'exploration sur le lymphœdème

Human Lymphatic Architecture and Dynamic Transport Imaged Using Near-infrared Fluorescence12

Human Lymphatic Architecture and Dynamic Transport Imaged Using Near-infrared Fluorescence12

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